Systematic Review of Immune Dysregulation in Tuberculosis-Diabetes Comorbidity

A systematic review synthesizing 81 studies published between 1974 and May 2023 on the immunological mechanisms linking diabetes mellitus (DM) and tuberculosis (TB). The document, authored by Aminat Y. Saula, examines how DM alters TB pathogenesis through immune dysregulation. The review was registered with PROSPERO (CRD42023431040) and is available as a 31.2 KB DOCX file.

Use Cases

• Identify key immune mechanisms altered by diabetes in tuberculosis based on the review's synthesis of innate and adaptive immune responses.
• Compare immunological profiles between active TB with DM and latent TB infection with DM based on the distinct immune profiles described.
• Investigate the impact of pre-diabetes on TB immunity based on the emerging evidence for intermediate hyperglycaemia mentioned in the results.
• Inform the design of host-directed therapeutic strategies for TB-DM patients based on the conclusions regarding metabolic optimisation.

Strengths

• Synthesizes findings from 81 eligible studies, providing a broad evidence base.
• Covers a long temporal range of research, from 1974 to May 2023.
• Examines multiple study approaches, including animal models and human participants.
• Is openly licensed under CC-BY-4.0 for reuse and redistribution.

Limitations

• The dataset is a 31.2 KB DOCX document, indicating a limited scope of raw data.
• Row count and column-level documentation are absent; the content structure must be inferred after download.
• The description metadata is limited; actual data quality requires manual inspection of the document.

Provenance

Source

figshare

Collection Method

Systematic review of published literature.

Time Range

Studies published between 1974 and May 31, 2023.

Freshness

Last updated 2026-04 23 04:21:49; freshness should be verified.

Geography

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