Table 2_Immune-inflammation index as prognostic markers in metastatic castration-resistant

A systematic review and meta-analysis of 36 studies involving 10,325 patients with metastatic castration-resistant prostate cancer (mCRPC). The work, authored by Zitong Qin and last updated in April 2026, synthesizes evidence on the association between blood-derived immune-inflammatory indices and survival outcomes. It followed PRISMA 2020 guidelines and was registered in the PROSPERO database.

Use Cases

• Validate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) for overall survival (OS) and progression-free survival (PFS) in mCRPC.
• Assess the association between platelet-to-lymphocyte ratio (PLR) and survival outcomes based on pooled hazard ratios.
• Investigate the relationship between systemic immune-inflammation index (SII) and worse OS in metastatic prostate cancer patients.
• Examine the prognostic significance of lymphocyte-to-monocyte ratio (LMR) for improved OS.
• Conduct subgroup analyses to explore the robustness of NLR/PLR associations across different clinical strata.

Strengths

• Includes 36 studies with a total of 10,325 patient records, providing a substantial evidence base.
• Reports pooled hazard ratios with 95% confidence intervals for multiple immune-inflammatory indices (NLR, PLR, SII, LMR).
• Follows PRISMA 2020 systematic review standards and is registered in the PROSPERO database (CRD420261291003).

Limitations

• The dataset is a 25.4 KB DOCX document, which is a text summary rather than raw patient-level data.
• Row and column-level data are unavailable, limiting direct analysis and reproducibility of the meta-analysis.
• The description does not specify the geographic origin of the included studies, which may affect generalizability.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from Embase, PubMed, Web of Science, and the Cochrane Library up to May 2025.

Time Range

Studies from database inception until May 2025.

Freshness

Last updated 2026-04-27 04:14:40