Central Obesity Impact on Esophageal Motility and Mucosal Barrier

A 2026 study by Jiang Guidong analyzes 185 patients stratified by visceral-to-subcutaneous fat ratio (V/S). It investigates associations between central obesity and esophageal metrics like lower esophageal sphincter pressure, acid exposure time, and mean nocturnal baseline impedance. The dataset includes patient demographics, GERD prevalence, and results from high-resolution manometry and 24-hour pH-impedance monitoring.

Use Cases

• Analyze the correlation between the visceral-to-subcutaneous fat ratio (V/S) and lower esophageal sphincter (LES) resting pressure across patient quartiles.
• Model the relationship between V/S quartile and acid exposure time (AET) or DeMeester score (DMS) to assess mucosal injury risk.
• Investigate how mean nocturnal baseline impedance (MNBI) Z3-Z6 varies with GERD prevalence across different V/S groups.
• Examine the association between esophagogastric junction contractile integral (EGJ-CI) and central obesity severity after adjusting for factors like Hiatal Hernia.

Strengths

• Contains data from 185 patients, providing a substantive clinical cohort for analysis.
• Includes multiple specific physiological metrics: V/S ratio, LES pressure, AET, DMS, MNBI, and EGJ-CI.
• Patients are stratified into four quartiles (Q1-Q4) based on V/S ratio, enabling comparative analysis.
• Data is derived from multiple diagnostic modalities: CT, high-resolution manometry, and 24-hour pH-impedance monitoring.

Limitations

• The dataset is very small at 15.4 KB, likely containing only summary statistics rather than raw patient-level data.
• As a retrospective study, it may have inherent selection biases not accounted for in the available data.
• Specific column definitions and raw data rows are unavailable, limiting detailed re-analysis.

Provenance

Source

Jiang Guidong via figshare.

Collection Method

Retrospective clinical study using data from patients who underwent gastroduodenoscopy, high-resolution manometry, 24-h pH-impedance monitoring, and abdominal CT.

Freshness

Last updated in March 2026.