Structured Transition Protocol for Paediatric Patients with Inborn Errors of Immunity

A practice-informed narrative review proposing a structured, multidisciplinary transition protocol for paediatric patients with inborn errors of immunity (IEI). The document integrates a non-systematic literature review, expert clinical consensus, and the practical experience of a dedicated Italian centre. It was authored by Adele Civino and last updated on May 11, 2026.

Use Cases

• Designing a clinical transition framework based on the proposed multidisciplinary model.
• Evaluating transition outcome indicators such as infection rates and follow-up adherence.
• Planning patient empowerment strategies and immunoglobulin replacement therapy options.
• Developing standardized documentation like clinical dossiers and final transition reports.

Strengths

• Provides a detailed, structured protocol with specific components like a three-year overlap period.
• Integrates expert clinical consensus and practical experience from a dedicated centre.
• Includes measurable process and outcome indicators such as patient-reported quality of life.

Limitations

• The document is a narrative review and lacks prospective validation of its proposed model.
• The framework is acknowledged to be resource-intensive, relying on multidisciplinary resources.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

Adele Civino via figshare.

Collection Method

Non-systematic appraisal of literature combined with expert clinical consensus and practical experience.

Freshness

Last updated 2026-05-11 04:20:59; freshness should be verified.

Geography

Based on experience from a dedicated Italian centre; adaptability to other settings is suggested.