Blautia and Indole-3-Acetic Acid Effects on Sepsis Lung Injury

Ke Chao's research data, published on figshare in March 2026, examines the role of the gut bacterium Blautia and its metabolite indole-3-acetic acid (IAA) in sepsis-induced acute lung injury. The dataset contains results from gut microbiome profiling, untargeted metabolomic analysis, and functional studies in a rat model and human patients. It supports the finding that Blautia-derived IAA mitigates lung injury by restoring CD8+ T cell populations.

Use Cases

• Analyze correlations between Blautia abundance and pulmonary injury severity scores from clinical patient data.
• Model the therapeutic effects of IAA administration on CD8+ T cell functional response metrics from rat model studies.
• Compare gut microbiome profiles, specifically Blautia depletion, between sepsis patients and healthy controls.

Strengths

• Data is directly tied to a published research study with specific findings on Blautia and IAA.
• Includes results from multiple methodological approaches: clinical analysis, animal models, and metabolomic profiling.
• Released under a permissive CC BY 4.0 license for broad reuse.

Limitations

• The dataset is very small at 13.1 KB, indicating limited scope and likely summary-level results rather than raw experimental data.
• Specific data structure, column names, and row counts are unknown, complicating direct analytical use.
• Findings are specific to sepsis-induced acute lung injury, limiting generalizability to other conditions.

Provenance

Source

figshare, authored by Ke Chao.

Collection Method

Generated from a research study involving gut microbiome profiling of patients, a cecal ligation and puncture rat model, untargeted metabolomic analysis, and functional immune assays.

Freshness

Last updated March 2026.