Table 2_Inflammatory protein mediators linking gut microbiota to degenerative lumbar spine

A 128.1 KB Excel file uploaded by Yongfu Lou on June 3, 2026, presents genetic evidence for causal pathways between gut microbiota, circulating inflammatory proteins, and degenerative lumbar spine disorders. The data was generated using two-sample Mendelian randomization on FinnGen R12 summary statistics and validated with rat model experiments. It includes results from mediation analyses quantifying indirect effects across 13 genetically supported pathways.

Use Cases

• Identify genetically predicted gut microbiota taxa associated with specific spinal disorders based on the 28, 20, and 41 taxa linked to LSS, spondylolisthesis, and IDD.
• Prioritize circulating inflammatory proteins for mechanistic studies based on the risk-increasing associations identified for IL-4, CXCL1, and others.
• Evaluate shared mediation pathways across diseases based on the 13 genetically supported GM–IPs–DLSD pathways with mediation proportions from 7.55% to 13.22%.
• Validate experimental models by comparing inflammatory marker and gut microbiota profiles from rat studies with the genetic findings.

Strengths

• Results are based on FinnGen R12 summary statistics, a large-scale genetic resource.
• Mediation analyses quantify indirect effects across 13 specific pathways with proportions ranging from 7.55% to 13.22%.
• Findings are supported by complementary sensitivity analyses, pleiotropy testing, and experimental validation in rat models.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the FinnGen cohort.

Provenance

Source

figshare

Collection Method

Two-sample Mendelian randomization using FinnGen R12 summary statistics, complemented by experimental validation in rat models.

Freshness

Last updated 2026-06-03 04:47:15; freshness should be verified.