Innate Immune Cell Profiles for Hypertensive and Normotensive Male Subjects

A 15.5 KB Excel dataset from a 2026 figshare upload contains results from a study profiling natural killer (NK) cells in male subjects. The data likely includes measurements from high-dimensional mass cytometry (CyTOF), flow cytometry, and single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs). The study compared 10 hypertensive and 10 normotensive male subjects in a discovery cohort and 10 hypertensive and 6 normotensive males in a validation cohort.

Use Cases

• Identify specific NK cell subpopulations (e.g., CD57+CD62L+CD161+) associated with hypertension based on the described profiling.
• Analyze transcriptional heterogeneity within the CD57+CD62L+CD161+ NK cell pool based on the single-cell RNA sequencing results mentioned.
• Investigate the relative abundance of subsets like the KLRC2high Adaptive and FCER1Ghigh Cytotoxic NK cells in hypertensive versus normotensive states.
• Explore correlations between immune cell profiles and clinical hypertension status as suggested by the cohort design.

Strengths

• Data is validated across two independent cohorts (discovery n=20, validation n=16) using complementary techniques (CyTOF and flow cytometry).
• Includes high-resolution single-cell RNA sequencing data for delineating transcriptional subsets within a specific NK cell population.
• Released under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset is small (15.5 KB), indicating it likely contains summary or processed results rather than raw, high-volume sequencing or cytometry files.
• The study population is limited to male subjects, which may affect generalizability.

Provenance

Source

figshare, author Xiaoqi Wang.

Collection Method

High-dimensional mass cytometry (CyTOF), full-spectrum flow cytometry, and single-cell RNA sequencing of sorted PBMCs from human subjects.

Time Range

Temporal coverage of the underlying study is not specified in the metadata.

Freshness

Last updated 2026-04-16 05:25:53; freshness should be verified.

Geography

Spatial coverage of the subject cohort is not specified in the metadata.