ASD Risk Genes with m6A Enrichment and Synaptic Overlap Analysis

This dataset integrates m6A-seq and CLIP-seq data with the SFARI gene database, finding 41.59% (515 of 1,238 genes) of Autism Spectrum Disorder risk genes are m6A-enriched. It specifically identifies 28 syndromic genes overlapping with the Synaptic m6A Epitranscriptome. The analysis was authored by Shreya Doijad and focuses on m6A readers like FMRP and YTHDF1.

Use Cases

• Analyze the overlap between the 1,238 ASD risk genes from SFARI and the m6A-enriched gene set to identify the 515 high-confidence candidates.
• Investigate the 28 syndromic genes within the Synaptic m6A Epitranscriptome (SME) for potential links to synaptic dysfunction in ASD.
• Examine the role of specific m6A reader proteins, such as FMRP and YTHDF1, using the integrated genetic data to model post-transcriptional regulation in ASD.

Strengths

• Integrates data from multiple published sources: m6A-seq, CLIP-seq, and the authoritative SFARI gene database.
• Provides a specific, quantified finding: 515 out of 1,238 ASD risk genes (41.59%) are identified as m6A-enriched.
• Focuses on a specific molecular mechanism, highlighting 28 syndromic genes overlapping with the Synaptic m6A Epitranscriptome.

Limitations

• The dataset is small in file size (201.8 KB), indicating limited raw data or a highly summarized analysis table.
• Underlying column structure and sample data are unavailable, limiting direct analytical reuse without the original study context.
• The analysis is a static integration of previously published data; it does not represent new primary experimental measurements.

Provenance

Source

Integration of published m6A-seq and CLIP-seq data with the SFARI gene database.

Collection Method

Computational integration and analysis of genetic and epigenomic datasets.

Freshness

Last updated on 2026-03-20.