TP53 H179 Mutation Analysis in NSCLC: Structural and Genomic Characterization

TP53 gene mutations were present in 50% of lung adenocarcinoma and 81% of lung squamous cell carcinoma cases analyzed. This dataset contains a research document analyzing the structural and functional impact of specific mutations at the His179 site in the p53 zinc-binding motif across 1,160 individuals from TCGA. The study by Ankur Datta, last updated in April 2026, used molecular dynamics simulations to assess protein stability and conformational changes.

Use Cases

• Analyze mutational profiles of TP53 in NSCLC subtypes based on the TCGA cohort data mentioned.
• Study the structural impact of zinc-binding motif mutations based on molecular dynamics simulation results.
• Compare conformational signatures and protein stability between wildtype and H179 mutant variants.
• Investigate residue-level interaction patterns in p53 mutants based on contact map analysis.

Strengths

• Analysis includes 1,160 individuals (616 LUAD and 544 LUSC) from TCGA.
• Focuses on a specific, underexplored structural site (His179) within a critical cancer gene.
• Employs multiple analysis methods: TCGA mutational profiles, static structural analysis, and molecular dynamics simulations.

Limitations

• Dataset is a 12.8 KB DOCX file, suggesting limited raw data and primarily a textual research summary.
• Row count and column-level documentation are absent; data structure must be inferred from the document.
• The file format (DOCX) may require conversion or manual extraction for computational analysis.

Provenance

Source

figshare, author Ankur Datta.

Collection Method

TCGA mutational profiles were evaluated, with structural analysis via molecular dynamics simulations.

Time Range

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Freshness

Last updated 2026-04-10 05:59:24

Geography

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