RGS4 Expression and Functional Data for SF-1 Lineage Pituitary Tumors

A 12.7 KB Excel file from figshare, last updated in April 2026, presents integrated single-cell and bulk RNA sequencing analysis of SF-1 lineage Pituitary Neuroendocrine Tumors (PitNETs). The dataset, authored by Changxi Han, identifies a proliferative tumor subgroup characterized by high expression of the gene RGS4. It includes results from functional experiments showing RGS4's role in promoting tumor cell proliferation via p53 destabilization.

Use Cases

• Identify molecular subgroups within SF-1 lineage PitNETs based on integrated transcriptomic profiles.
• Validate the correlation between RGS4 expression levels and clinical markers like tumor size and proliferation index.
• Investigate the RGS4-p53 axis as a potential therapeutic target for a subset of pituitary tumors.
• Benchmark new single-cell or bulk RNA-seq analysis pipelines against a focused oncology dataset.

Strengths

• Data is derived from an integrated analysis of both single-cell and bulk RNA sequencing, which can provide multi-resolution insights.
• Functional validation through gain/loss-of-function experiments is described, suggesting a link between the identified biomarker and tumor biology.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain statistical analyses.
• The 12.7 KB file size indicates a very small dataset, likely containing summary or processed results rather than raw sequencing data.

Provenance

Source

figshare, author Changxi Han.

Collection Method

Integrated analysis of single-cell and bulk RNA sequencing data from SF-1 lineage PitNETs, followed by functional experiments in cell lines.

Freshness

Last updated 2026-04-22 05:49:43; freshness should be verified.