ARHGEF12 Genotype and Netarsudil Response in 1,844 Glaucoma Subjects

1,844 African ancestry subjects with primary open-angle glaucoma were analyzed to investigate the association between ARHGEF12 genetic variants and therapeutic response to the Rho-kinase inhibitor netarsudil. The dataset, authored by Anusha Mamidipaka and last updated in May 2026, includes analysis of a 66-subject subset where intraocular pressure reduction was measured over 12 months. Preliminary findings suggest ARHGEF12 variant status does not strongly predict netarsudil response.

Use Cases

• Analyze the relationship between ARHGEF12 genotype and baseline glaucoma severity based on demographic and ocular phenotypes.
• Model intraocular pressure reduction over time in response to netarsudil treatment based on genotype groups.
• Investigate pharmacogenetic associations for Rho-kinase inhibitors using the subset of 66 treated subjects.
• Compare secondary ocular measures like cup-to-disc ratio and retinal nerve fiber layer thickness across genetic carriers.

Strengths

• Includes data from 1,844 subjects, providing a substantial cohort for baseline analysis.
• Contains longitudinal response data for a subset of 66 subjects (114 eyes) over a 12-month period.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and analysis.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The authors describe the results as exploratory, noting the need for future studies with larger, treatment-naïve cohorts.
• The dataset is very small at 16.5 KB, indicating limited scope, likely containing summary results rather than raw patient-level data.

Provenance

Source

figshare

Collection Method

Clinical analysis comparing baseline phenotypes and therapeutic response across genotype groups using generalized estimating equations.

Time Range

Study period includes a 12-month follow-up for treatment response.

Freshness

Last updated 2026-05-08 05:48:19; freshness should be verified.

Geography

Subjects are of African ancestry; specific geographic locations are not stated.