Kangxianhuanji Formula Study on Acute Pulmonary Fibrosis

A research document detailing a study on the Kangxianhuanji herbal formula for treating acute exacerbation of idiopathic pulmonary fibrosis. The study used a bleomycin-induced mouse model, network pharmacology, proteomics, and molecular docking to identify GLUT1 and rutin as key targets. The document was authored by Siyuan Zhu and last updated in April 2026.

Use Cases

• Analyze the anti-inflammatory effects of Kangxianhuanji Formula based on described reductions in IL-1β, IL-6, TNF-α, and HMGB1.
• Study glycolytic reprogramming in fibrosis based on described changes in GLUT1, HIF-1α, HK2, and lactate production.
• Validate network pharmacology predictions for herbal compounds based on the described use of DARTS, LC-MS/MS, and molecular docking.
• Investigate macrophage activity in pulmonary disease based on described anti-inflammatory and anti-glycolytic effects of rutin.

Strengths

• The study employs multiple validation methods, including histopathology, proteomics, and cellular assays.
• The document identifies a specific bioactive component (rutin) and a core molecular target (GLUT1).

Limitations

• The dataset is a single 16.0 KB DOCX file, suggesting limited raw data scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Research study involving mouse models, network pharmacology, and molecular validation.

Freshness

Last updated 2026-04-24 04:22:34; freshness should be verified.