PARP Knockout Mouse Histopathology and Cytokine Data for Colitis Study

A 10.2 KB Excel dataset from figshare, authored by Haoran Ke and last updated on 2026-05-19. It contains results from a study investigating spontaneous colitis in double PARP1/PARP2 knockout mice, comparing them to control and single knockout animals. The data likely includes histological scores, cytokine levels, and cell density measurements from the large intestines.

Use Cases

• Modeling the distinct segmental effects of PARP deficiency on intestinal inflammation based on the described proximal vs. distal differences.
• Analyzing correlations between T cell density, oxidative stress markers, and cytokine levels like TNFα mentioned in the results.
• Investigating the relationship between crypt morphology, cell proliferation (Ki-67), and apoptosis (caspase-3) in genetically modified mouse intestines.
• Comparing inflammatory signaling protein activation between single and double knockout genotypes as described in the study.

Strengths

• Dataset is openly licensed under CC-BY-4.0, permitting reuse and redistribution.
• The underlying study employs multiple immune-based methods (histopathology, immunohistochemistry, ELISA, Western blot) for validation.
• Data is focused on a specific, genetically defined experimental model (PARP1-deficient mice with T-cell-specific PARP2 knockout).

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• The dataset is very small (10.2 KB), indicating limited scope, likely containing summary or key result tables rather than raw experimental data.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare

Collection Method

Generated from crossbreeding single knockout mice and analyzing large intestines via histopathology and immune-based assays.

Freshness

Last updated 2026-05-19 05:29:31; freshness should be verified.