NHANES 2005-2008 Blood Lead Levels and Retinal Vein Occlusion Association Data

A dataset of 5,415 participants from the 2005-2008 NHANES survey, analyzing the relationship between blood heavy metal concentrations and retinal vein occlusion. It includes results from multivariate logistic regression and RNA sequencing of lead-treated endothelial cells, identifying 166 differentially expressed genes. The dataset was authored by Shuai Yang and last updated in May 2026.

Use Cases

• Assessing the association between blood lead levels and retinal vein occlusion risk based on NHANES survey data.
• Investigating the transcriptomic effects of lead exposure on endothelial cells based on RNA sequencing results.
• Validating the role of specific genes like PRICKLE4 and PLCXD1 in lead-induced vascular pathways.
• Exploring the combined effects of multiple heavy metal exposures on ocular health using multi-exposure modeling.

Strengths

• Includes data from 5,415 participants from a nationally representative survey (NHANES).
• Contains results from RNA sequencing identifying 166 common differentially expressed genes.
• Uses a fully adjusted multivariate logistic regression model, reporting specific p-values (e.g., p=0.0111).

Limitations

• Row count for the primary analysis dataset is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (20.0 KB), indicating it likely contains summary statistics rather than raw individual-level data.

Provenance

Source

National Health and Nutrition Examination Survey (NHANES) 2005-2008.

Collection Method

Multivariate logistic regression on survey data and RNA sequencing on HUVECs treated with lead nitrate.

Time Range

Survey data from 2005 to 2008.

Freshness

Last updated 2026-05-12 05:42:55; freshness should be verified.

Geography

United States (NHANES).