Limited Adaptability of Virtual Memory CD8 T Cells to Chronic Viral Infection

This dataset likely contains experimental results from a study comparing naïve and virtual memory (VM) CD8 T cell responses during chronic lymphocytic choriomeningitis virus infection. VM CD8 T cells showed a diminished response to persistent antigen, impaired engagement of the exhaustion program due to lower TOX expression, and reduced TCF1+ stem-like cells. The data supports findings on VM cell differentiation into KLRG1+PD-1- cells and limited expansion following PD-1 blockade.

Use Cases

• Comparing naïve and virtual memory CD8 T cell responses based on phenotypic and functional markers
• Analyzing T cell exhaustion program engagement using TOX and TCF1 expression data
• Investigating differentiation pathways into KLRG1+PD-1- cell populations
• Evaluating the impact of PD-1 blockade on VM-derived CD8 T cell expansion

Strengths

• Dataset is available under a CC-BY-4.0 license, facilitating open reuse
• Cross-platform presence on figshare indicates established sharing and potential importance

Limitations

• Column names and row counts are not provided, limiting understanding of data structure
• Multiple file sizes are listed (e.g., 14088, 12864, 10501) without explanation, suggesting possible versioning or format differences

Provenance

Source

Yamato Sajiki

Collection Method

Likely generated from experiments using a chronic lymphocytic choriomeningitis virus infection model

Freshness

Last updated on 2026-05-22