Zebrafish shox/shox2 Gene Knockdown Effects on fgfr3 and Natriuretic Peptides

A zebrafish model study by Sandra Hoffmann, last updated April 2026, investigates the mutual regulation of shox and shox2 genes and their tissue-specific effects on fgfr3 and natriuretic peptide gene expression. The 24.7 KB Excel file contains results from experiments analyzing expression patterns in whole embryos, fins, heart, and brain. Findings suggest implications for human SHOX deficiency and potential CNP therapy.

Use Cases

• Analyze tissue-specific gene co-regulation patterns based on shox and shox2 expression data.
• Model relationships between transcription factor deficiency and receptor expression based on fgfr3 levels.
• Investigate cardiac stress markers based on nppb expression changes in heart tissue.
• Study potential therapeutic pathways based on the interaction between CNP treatment and fgfr3 levels.

Strengths

• Data is derived from a controlled experimental model (zebrafish) examining specific gene interactions.
• The dataset is associated with a detailed biological description of tissue-specific effects.
• It is shared under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is very small at 24.7 KB, indicating limited scope.
• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Data may reflect experimental bias inherent to the specific zebrafish study design.

Provenance

Source

figshare

Collection Method

Experimental data from zebrafish gene knockdown studies.

Freshness

Last updated 2026-04-17 04:11:54; freshness should be verified.