Lipid Profiles and Late-Onset Ischemic Stroke in Adults Aged 60+

565 lipid-lowering therapy-naive patients with first-ever acute ischemic stroke were stratified by age to analyze lipid patterns. The oldest-old group (≥80 years) showed significantly lower levels of total cholesterol, triglycerides, LDL-C, and other lipid markers compared to younger cohorts. This retrospective study by Shusheng Jiao, published in 2026, identifies non-HDL-C as the strongest lipid predictor of late-onset stroke.

Use Cases

• Identify age-specific lipid predictors of ischemic stroke based on total cholesterol, triglycerides, and LDL-C levels.
• Compare dyslipidemia subtype prevalence across age groups (60-69, 70-79, ≥80 years).
• Investigate gender-specific associations between lipid markers (LDL-C in females, triglycerides in males) and stroke risk.
• Evaluate the clinical utility of non-HDL-C as a co-primary target for lipid control in public health strategies.

Strengths

• Includes 565 patient records with strict exclusion criteria for prior lipid-lowering therapy.
• Analyzes multiple lipid parameters including total cholesterol, triglycerides, apolipoprotein B, LDL-C, VLDL-C, and non-HDL-C.
• Conducts multivariate regression to identify key predictors and reports gender-specific variations.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect temporal bias inherent to the single-center study period (March 2022 to June 2025).

Provenance

Source

Shusheng Jiao via figshare

Collection Method

Retrospective cohort analysis of consecutively enrolled patients.

Time Range

March 2022 to June 2025

Freshness

Last updated 2026-05-15 04:26:40; freshness should be verified.