Longitudinal Mouse Data on Lung Injury, Gut Flora, and Metabolism

Longitudinal multi-omics data tracks lung pathology, gut microbiome, and serum metabolome in mice over 15 days post-influenza infection following cigarette smoke exposure. Zhihang Liu published this 10.1 KB Excel dataset on figshare in April 2026. It supports research into biomarkers for acute exacerbations of chronic obstructive pulmonary disease.

Use Cases

• Identify serum metabolic biomarkers like 1-Methylnicotinamide (1-MNA) for classifying acute exacerbation stages using random forest models.
• Analyze correlations between gut microbiota abundance (e.g., Intestinimonas) and pulmonary inflammatory markers across longitudinal time points.
• Model the downregulation of serum unsaturated fatty acid biosynthesis pathways from day 3 to day 15 post-infection and its link to lung inflammation.
• Examine longitudinal changes in lung function metrics, immune cell recruitment, and emphysematous pathology following combined smoke and viral exposure.

Strengths

• Integrates three data modalities: lung pathology/function, 16S rRNA gut microbiome sequencing, and untargeted serum/fecal metabolomics.
• Provides longitudinal coverage with assessments from day 1 to day 15 post-infection, capturing dynamic biological shifts.
• Dataset is openly licensed under CC-BY-4.0, enabling reuse and redistribution.

Limitations

• Very small data scale at 10.1 KB, indicating a summary table rather than raw, high-volume omics data.
• Limited to a single mouse model study, restricting generalizability to human populations.
• Specific row counts, column names, and sample-level data are unavailable for direct computational analysis.

Provenance

Source

figshare, authored by Zhihang Liu.

Collection Method

Experimental mouse study with cigarette smoke exposure for eight weeks followed by influenza A virus infection; data generated via histopathology, lung function tests, 16S rRNA sequencing, and mass spectrometry metabolomics.

Time Range

Longitudinal measurements from day 1 to day 15 post-viral infection.

Freshness

Last updated April 2026.

Geography

Study location unknown; data derived from a controlled laboratory mouse model.