Erxing Tao's dataset, last updated May 20, 2026, contains proteomic and genetic analysis results from a study of Neurofibromatosis types 1 and 2. The 94.4 KB CSV file likely includes data on differentially expressed proteins and loss of heterozygosity for the EPB41L3 gene. The study involved 15 patients and identified 159 proteins differentially expressed in NF1 and 180 in NF2.
Use Cases
- Identify common differentially expressed proteins in NF1 and NF2 tumors based on the proteomic profiles described.
- Analyze the correlation between EPB41L3 loss of heterozygosity and tumor type based on the reported 60% prevalence in NF1 versus 20% in NF2.
- Investigate relationships between EPB41L3 expression and neurofibromin/Merlin levels based on Western blot analysis results mentioned.
- Validate potential therapeutic targets for neurofibroma syndromes based on the molecular mechanisms explored in the study.
Strengths
- Data is derived from a described study employing multiple techniques: Sanger sequencing, TMT-labeled spectrometry, RNA sequencing, Western blot, and immunofluorescence.
- Includes specific quantitative findings, such as 159 proteins differentially expressed in NF1 and 180 in NF2, with 11 commonly upregulated and 30 commonly downregulated.
- Released under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.
Limitations
- Row count and column definitions are unknown, requiring manual inspection after download to understand the data structure.
- The dataset is very small (94.4 KB), indicating limited scope, likely containing summary or processed results rather than raw experimental data.
- Description metadata is limited; actual data quality and completeness require manual inspection after download.
Provenance
- Source
- figshare, author Erxing Tao
- Collection Method
- Generated from a research study involving mutational analysis, proteomic profiling via TMT-labeled spectrometry, and protein expression evaluation.
- Time Range
- null
- Freshness
- Last updated 2026-05-20 04:33:14; freshness should be verified.
- Geography
- null