Table 4: Rab44 Knockout Effects on Murine Asthma Model

Rab44-knockout and wild-type mouse data from a study investigating the role of the Rab44 gene in ovalbumin-induced allergic airway inflammation. The dataset likely contains results from RNA sequencing, histopathological analysis, and assays measuring eosinophil function, adhesion, and chemotaxis. It supports analysis of immune response pathways and cellular mechanisms in a murine asthma model.

Use Cases

• Comparing gene expression pathways between Rab44-KO and WT mice using RNA-seq data.
• Analyzing the impact of Rab44 deficiency on eosinophil differentiation and degranulation.
• Investigating cell adhesion and chemotaxis impairment in knockout eosinophils.
• Correlating surface receptor expression with functional assays in allergic inflammation.

Strengths

• Data is derived from a controlled experimental study with genetically modified (Rab44-KO) and wild-type mouse cohorts.
• Includes results from multiple assay types: RNA-seq, flow cytometry, histopathology, and cellular functional assays.
• Available under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• Column names and exact row counts are not provided in the metadata, limiting immediate assessment of data structure.
• The dataset appears to be split across multiple files of varying sizes (39KB, 47KB, 1.8MB) with unclear distinctions.
• Primary data is from a murine model, which may limit direct translational insights for human asthma.

Provenance

Source

Experimental study by Haruka Mawatari, published on figshare.

Collection Method

Generated from laboratory experiments on mice, including RNA sequencing, flow cytometry, and cellular assays.

Time Range

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Freshness

Last updated 2026-05-21.

Geography

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