NHANES 1999–2018: TyG Index Association with Melanoma Prevalence and Mortality

United States data from 21,360 participants in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018, used to investigate the relationship between the triglyceride-glucose (TyG) index and melanoma. The study, authored by Yao Liang and last updated in March 2026, also includes an external validation cohort of 475 patients with primary non-metastatic acral melanoma from three tertiary hospitals. Analysis employed weighted logistic and Cox regression, restricted cubic splines, and seven machine learning algorithms.

Use Cases

• Train machine learning models for melanoma risk prediction based on demographic and metabolic markers like the TyG index.
• Analyze the U-shaped association between the TyG index and all-cause mortality in melanoma patients.
• Conduct subgroup analyses to verify the robustness of associations across different population segments.
• Interpret predictive models for melanoma using SHAP values to identify key factors like race, age, and serum phosphorus.

Strengths

• Includes a primary cohort of 21,360 participants from a nationally representative survey (NHANES).
• Uses an external validation cohort of 475 hospital patients for descriptive analysis.
• Applies seven machine learning algorithms and SHAP analysis for model interpretability.
• Covers a 20-year time period (1999–2018) for longitudinal mortality analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the primary data tables is unknown, which may limit suitability assessment.
• The dataset is very small (12.4 KB), suggesting it may contain summary or processed results rather than raw participant-level data.

Provenance

Source

National Health and Nutrition Examination Survey (NHANES) and three tertiary hospitals.

Collection Method

Cross-sectional survey data analysis with external hospital-based validation.

Time Range

1999–2018

Freshness

Last updated 2026-03-18 05:35:03; freshness should be verified.

Geography

United States