Systematic Review of Managed Entry Agreements for Pharmaceuticals

A systematic review of 96 studies mapping the global landscape of Managed Entry Agreements (MEAs) for pharmaceuticals. The review, authored by Hussain Abdulrahman Al-Omar and published on figshare in April 2026, synthesizes evidence on policy frameworks, implementation challenges, and regional evidence gaps. It follows PRISMA guidelines and covers literature from MEDLINE and EMBASE up to March 2025.

Use Cases

• Analyzing regional evidence gaps in MEA policy research based on the reported focus on European (43%) and North American (28%) systems.
• Identifying common implementation barriers for health systems based on themes like inefficient regulatory frameworks (42% of studies) and data infrastructure limitations (41%).
• Mapping stakeholder representation in MEA literature based on the noted underrepresentation of academia and civil society.
• Reviewing the coverage of Advanced Therapy Medicinal Products (ATMPs) based on the finding that 15% of studies focused on them.

Strengths

• Follows a structured, reproducible methodology using PRISMA guidelines for systematic review.
• Provides quantitative synthesis of findings from 96 included studies, including specific percentages for themes and barriers.
• Explicitly licensed under CC-BY-4.0 for open reuse.

Limitations

• The dataset is a 674 KB DOCX document; the underlying data tables or extracted study records are not provided as structured data.
• Row count and column-level documentation are unknown, limiting suitability assessment for quantitative analysis.
• The review notes a significant evidence gap for the Middle East and low-income countries, indicating potential geographic bias in the source literature.

Provenance

Source

figshare

Collection Method

Systematic review following PRISMA guidelines, searching MEDLINE and EMBASE from inception to March 2025.

Time Range

Literature covered up to March 2025.

Freshness

Last updated 2026-04-20 05:23:21.

Geography

Global focus, with studies primarily from European and North American systems.