Maternal Probiotic Supplementation and Offspring Health Umbrella Review

An umbrella review of 18 systematic reviews, with 13 providing meta-analyses covering 62 specific offspring-related outcomes. It re-analyzes evidence on maternal probiotic supplementation during pregnancy and lactation, focusing on outcomes like eczema risk and breast milk microbiota. The work was conducted by Wenrui Sun and includes data up to June 15, 2025.

Use Cases

• Analyze the 62 specific offspring-related outcomes to identify patterns in health effects reported across systematic reviews.
• Evaluate the GRADE certainty ratings and AMSTAR-2 quality assessments for evidence on outcomes like eczema risk.
• Examine the reported risk ratios (RR) and standardized mean differences (SMD) for associations with outcomes such as pathogenic bacteria in breast milk.
• Investigate the sensitivity analysis results showing 65% of associations lost significance under more conservative methods.

Strengths

• Synthesizes evidence from 18 systematic reviews, providing a high-level overview of the research field.
• Includes re-analysis of meta-analyses from 13 reviews, covering 62 distinct offspring health outcomes.
• Applies standardized quality and certainty assessments using AMSTAR-2 and GRADE frameworks.

Limitations

• The dataset is a single 87.6 KB document, not a structured tabular dataset, limiting computational analysis.
• All statistically significant associations from the included reviews were rated as having weak credibility.
• The review is based on existing systematic reviews up to mid-2025, not primary data, which may inherit biases from the source studies.

Provenance

Source

figshare, authored by Wenrui Sun.

Collection Method

Umbrella review of systematic reviews with meta-analyses, sourced from PubMed, Embase, CINAHL, Web of Science, and Cochrane Library.

Time Range

Literature search up to June 15, 2025.

Freshness

Last updated March 26, 2026, with literature search current up to June 15, 2025.

Geography

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