Maternal TSH and FT4 Changes During Pregnancy as Risk Factors for Preeclampsia

A retrospective study investigates associations between thyroid hormone changes and preeclampsia risk in euthyroid women. The analysis uses restricted cubic spline and logistic regression models on data from an unspecified number of participants. The dataset was authored by Jianxia Lin and last updated on 2026-05-26.

Use Cases

• Predicting preeclampsia risk based on TSH and FT4 level changes during pregnancy.
• Analyzing associations between thyroid function decompensation and pregnancy complications like preterm birth and low birth weight.
• Calculating population-attributable risk for preeclampsia based on specific thyroid hormone change patterns.

Strengths

• The study identifies specific threshold effects (TSH threshold 0.68 mIU/L) and risk groups (Complete Decompensation group).
• It reports adjusted odds ratios (aOR) for preeclampsia (1.89) and related complications (preterm birth aOR=3.35, low birth weight aOR=2.46).
• Sensitivity analyses were performed to confirm the robustness of the findings.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (15.2 KB), indicating limited scope, likely containing summary results rather than raw patient-level data.

Provenance

Source

figshare

Collection Method

Retrospective study using statistical models (restricted cubic spline, logistic regression).

Freshness

Last updated 2026-05-26 04:39:17; freshness should be verified.