Table 2_Mechanistic and functional characterization of NETs/IL-17 as a therapeutic target

A research document details the role of IL-17A-induced neutrophil extracellular traps (NETs) in promoting epithelial-mesenchymal transition and brain metastasis in lung adenocarcinoma. The study, authored by Yong Cai and published on figshare in 2026, employed LASSO and Cox regression analyses, survival assays, and in vitro/in vivo models. Findings suggest a potential association between the IL-17A/NETs/H2BC4 pathway and metastasis progression, highlighting possible therapeutic targets.

Use Cases

• Investigate gene expression patterns related to neutrophil extracellular traps (NETs) based on the described LASSO and Cox regression analyses.
• Study the role of IL-17A signaling in epithelial-mesenchymal transition (EMT) based on the described in vitro and in vivo models.
• Analyze promoter region enrichment of proteins like acetylated H2BC4 and p300 based on the described ChIP-qPCR and Co-IP results.
• Explore potential therapeutic targets for lung adenocarcinoma brain metastasis based on the described suppression by PAD inhibitors or DNase I.

Strengths

• The document is licensed under CC-BY-4.0, allowing for open sharing and adaptation.
• The research methodology is explicitly described, including LASSO/Cox regression, survival assays, and in vivo/in vitro models.

Limitations

• The dataset is a 17.0 KB DOCX file, indicating a very limited textual scope rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred from the narrative description.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Research study involving bioinformatics analysis (LASSO, Cox regression) and experimental validation (survival assays, in vitro/in vivo models).

Freshness

Last updated 2026-05-25 06:05:25; freshness should be verified.