Table 2_Melanoma stem cells drive macrophage reprogramming to a hybrid phenotype, modulati

Data from a 2026 study investigating how melanoma stem cells reprogram macrophages, impairing natural killer cell function. The dataset, shared under a CC-BY-4.0 license by author Martina Anselmi on figshare, includes results from in vitro experiments using A375 and WM115 cell lines and exploratory analysis of a melanoma patient cohort. Findings link a stem cell-educated macrophage score to inflammatory programs and shorter overall survival.

Use Cases

• Train models to predict macrophage phenotype based on stem cell signaling factors mentioned in the description
• Analyze associations between stem cell-educated macrophage gene signatures and patient survival outcomes referenced in the results
• Investigate the relationship between melanoma stemness-associated transcriptional regulators and NK-cell cytotoxicity impairment described in the study

Strengths

• Dataset is 1.1 MB, indicating a manageable size for quick inspection and analysis.
• Includes data from both controlled in vitro models (A375, WM115 cell lines) and an independent melanoma patient cohort, as described in the methods.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Generated from in vitro melanosphere cultures, THP-1 monocyte differentiation experiments, RNA-seq, and analysis of a clinical melanoma cohort, as described.

Freshness

Last updated 2026-06-02 05:42:38; freshness should be verified.