Oral CBD Effects and Pharmacokinetics in Connemara Ponies Over 21 Days

A dataset from a study evaluating the metabolic effects and pharmacokinetics of oral cannabidiol (CBD) in 13 Connemara ponies over a 21-day treatment period. The study, authored by Kata Wermer and shared on figshare under CC-BY-4.0, measured body weight, body condition score, cresty neck score, and blood parameters including glucose, insulin, triglycerides, and CBD concentrations. Results showed CBD did not significantly affect most metabolic parameters but was associated with an increased insulin response during an oral sugar test.

Use Cases

• Analyze pharmacokinetic parameters like Cmax and Tmax based on plasma CBD concentration data mentioned in the description.
• Compare insulin and glucose response changes between CBD-treated and control groups based on oral sugar test results.
• Investigate potential drug accumulation based on the reported accumulation ratio and steady-state timeline.
• Assess safety and tolerability of CBD treatment in ponies based on monitored clinical parameters.

Strengths

• Includes data from 13 Connemara ponies, with 7 diagnosed with equine metabolic syndrome.
• Reports specific pharmacokinetic results, including a Cmax increase from 22.79 to 39.93 ng/mL and an accumulation ratio of 2.75.
• Contains longitudinal data from a 21-day treatment period with pre- and post-treatment measurements.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 15.5 KB, indicating limited scope.

Provenance

Source

figshare, author Kata Wermer.

Collection Method

Data collected from a controlled clinical trial with 13 ponies randomly assigned to CBD or control groups.

Time Range

Covers a 21-day treatment period.

Freshness

Last updated 2026-05-14 04:25:22; freshness should be verified.

Geography

Study conducted on Connemara ponies; specific location not stated.