Metabolic Profiles of PCOS-like Endometrial Organoid Fluids

Metabolomic data from a study constructing three endometrial organoid cases to model Polycystic Ovary Syndrome (PCOS). The dataset compares Intra-Organoid Fluid (IOF) and Extra-Organoid Fluid (EOF) profiles, identifying altered amino acid and fatty acid metabolism. It was generated by Haoxuan Yang and published on figshare in March 2026.

Use Cases

• Analyze glutamine metabolic changes in the Extra-Organoid Fluid (EOF) to investigate its role in endometrial stromal cell decidualization.
• Compare fatty acid metabolite profiles in the Intra-Organoid Fluid (IOF) across different androgen-treatment groups.
• Correlate specific metabolic pathway alterations in EOF and IOF with simulated PCOS-like characteristics from the organoid model.
• Screen for potential metabolic markers in organoid fluids related to implantation failure in PCOS.

Strengths

• Data is derived from a controlled, high-androgen organoid model simulating PCOS-like characteristics.
• Metabolomic profiles were generated using high-throughput quantitative analysis for both IOF and EOF.
• The dataset is openly shared under a CC BY 4.0 license.

Limitations

• The dataset is very small at 10.3 KB, indicating limited scope and likely a summary table rather than raw experimental data.
• It is based on only three cases of endometrial organoids, limiting statistical power and generalizability.
• The specific columns, row count, and sample data are unavailable, hindering a detailed assessment of its structure.

Provenance

Source

figshare, author Haoxuan Yang.

Collection Method

Metabolomic analysis of fluid from in vitro endometrial organoids treated with estradiol and testosterone to simulate PCOS.

Freshness

Last updated March 2026.