Rat Cerebral Cortex Transcriptome and Metabolome Profiles After Subarachnoid Hemorrhage

Transcriptomic and metabolomic profiles of the rat cerebral cortex following experimental subarachnoid hemorrhage (SAH). The dataset includes 982 differentially expressed genes and 540 differentially expressed metabolites at 1 day post-SAH, and 292 differentially expressed genes and 254 differentially expressed metabolites at 7 days post-SAH. It was created by Haoran Lu and shared on figshare under a CC-BY-4.0 license.

Use Cases

• Identify immune and inflammatory pathway activation based on differentially expressed genes involved in Complement and coagulation cascades, TNF, and NOD-like receptor signaling.
• Analyze metabolic pathway disruptions based on affected pathways including Arginine and proline, Arachidonic acid, and Folate biosynthesis.
• Investigate potential therapeutic targets based on metabolites associated with oxidative stress, endothelial damage, and blood-brain barrier disruption.
• Study temporal molecular changes based on comparisons between sham, 1-day post-SAH, and 7-day post-SAH time points.

Strengths

• Integrates two omics data types: transcriptome and metabolome profiles.
• Reports specific counts of differentially expressed entities: 982 genes and 540 metabolites at 1 day, 292 genes and 254 metabolites at 7 days.
• Data collection methods are specified: whole transcriptome sequencing and untargeted metabolomics assays.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (9.7 KB), indicating a limited scope, likely containing summary results rather than raw sequencing data.

Provenance

Source

figshare, author Haoran Lu.

Collection Method

Data generated via whole transcriptome sequencing and untargeted metabolomics assays on rat cerebral cortex tissue.

Time Range

Covers time points at 1 day and 7 days post-subarachnoid hemorrhage, compared to a sham group.

Freshness

Last updated 2026-04-28 14:40:41; freshness should be verified.