Differential expression data for microRNAs in canine visceral hemangiosarcoma, derived from formalin-fixed, paraffin-embedded tissues. The dataset includes results from 24 dogs with histologically confirmed HSA and 12 non-neoplastic controls, with 13 validated miRNAs per tissue type. It was authored by Laura Machado Ribas and last updated on March 17, 2026.
Use Cases
- Identify potential diagnostic biomarkers for canine visceral hemangiosarcoma based on validated microRNA expression.
- Perform pathway enrichment analysis based on the oncogenic signaling pathways (e.g., PI3K-Akt, MAPK) mentioned in the results.
- Compare microRNA signatures between splenic and cardiac tumor types based on the 18 shared differentially expressed miRNAs.
- Assess the utility of archived FFPE tissues for biomarker discovery as highlighted in the discussion.
Strengths
- Includes data from 24 dogs with confirmed HSA and 12 non-neoplastic controls.
- Reports 13 validated differentially expressed microRNAs for each tissue type.
- Pathway analysis reveals involvement in specific oncogenic signaling pathways like PI3K-Akt and MAPK.
Limitations
- Row count and column-level documentation are absent; field semantics must be inferred after download.
- The dataset is very small at 10.9 KB, indicating limited scope.
- Data may reflect bias inherent to the specific sample collection described.
Provenance
- Source
- figshare
- Collection Method
- Analysis of FFPE tissues using small RNA sequencing and quantitative PCR.
- Time Range
- null
- Freshness
- Last updated 2026-03-17 14:40:01; freshness should be verified.
- Geography
- null