Pediatric Asthma-Obesity Comorbidity Circulating miRNA Profiles

A 2026 exploratory study by Harshita Shailesh profiles circulating microRNA signatures from whole blood samples of 43 children across four groups: normal weight with asthma, overweight/obese with asthma, overweight/obese without asthma, and normal weight without asthma. The dataset likely contains miRNA expression data analyzed via the NanoString nCounter platform, identifying shared dysregulation patterns. It is published under a CC-BY-4.0 license on figshare.

Use Cases

• Identify biomarker candidates for asthma-obesity comorbidity based on shared miRNA signatures.
• Investigate molecular pathways like IL-4/IL-13 signaling based on target gene analysis results.
• Correlate miRNA expression with clinical parameters like neutrophil counts and lung function.
• Validate potential therapeutic targets for pediatric asthma management in the context of obesity.

Strengths

• Includes data from 43 pediatric participants across four distinct clinical groups.
• Identifies seven specific miRNAs (e.g., miR-423-3p, miR-144-3p) with consistent dysregulation patterns.
• Correlates miRNA findings with clinical and cytokine data, providing a multi-modal view.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 15.7 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Cross-sectional study using whole blood samples analyzed via NanoString nCounter platform.

Freshness

Last updated 2026-05-13 04:57:47; freshness should be verified.