Molecular Epidemiology of Carbapenem-Resistant Enterobacter Cloacae in Northeast China

Northeast China data characterizes 123 clinical carbapenem-resistant Enterobacter cloacae complex (CRECC) isolates collected from July 2019 to March 2025. The dataset includes genomic and phenotypic analysis results, with Enterobacter hormaechei as the predominant species (92.7%) and bla_NDM-5 (55.3%) as the primary resistance gene. It was produced by Ze Li using whole-genome sequencing to study transmission dynamics and resistance mechanisms.

Use Cases

• Analyze the distribution of resistance genes like bla_NDM-5 and bla_NDM-1 across the 123 CRECC isolates to map regional resistance patterns.
• Investigate the association between clonal lineages (e.g., ST171, ST1120) and plasmid types (e.g., IncX3) to understand transmission mechanisms.
• Study the phenotypic resistance data, such as MIC90 values for meropenem and imipenem, in relation to specific genotypic findings.
• Examine the results of conjugation experiments (28.0% success rate) to assess the horizontal transfer potential of resistance plasmids.

Strengths

• Dataset contains 123 clinically sourced isolates, providing a substantive sample for regional analysis.
• Includes detailed genotyping results for species, subspecies, sequence types (ST), and resistance genes.
• Phenotypic data, such as antimicrobial susceptibility testing and carbapenemase production confirmation, is linked to genomic findings.
• Clear temporal coverage from July 2019 to March 2025 tracks recent evolution and spread.

Limitations

• The dataset is small in file size (23.7 KB), indicating limited raw data or a highly summarized format, which restricts deep genomic re-analysis.
• Geographic scope is limited to Northeast China, limiting generalizability to other regions.
• Sample data and column structure are unavailable, making preliminary assessment of data organization difficult.

Provenance

Source

Ze Li, published on figshare.

Collection Method

Data generated from whole-genome sequencing, antimicrobial susceptibility testing, plasmid analysis, and conjugation experiments on clinical isolates.

Time Range

July 2019 to March 2025.

Freshness

Data is current, last updated on March 23, 2026.

Geography

Northeast China.