Molecular Insights into CRIP1 from Knockout Mice and Single-Cell RNA Sequencing

A 2026 study by DoYeon Kim provides integrated transcriptomic data from CRIP1 knockout and wild-type mouse liver tissues and single-cell RNA sequencing of human peripheral mononuclear cells. The 17.1 KB DOCX file details analyses of zinc transport, iron metabolism, mitochondrial oxidative phosphorylation, and inflammatory gene profiles across immune cell subsets.

Use Cases

• Compare zinc transport and iron metabolism gene expression between CRIP1 knockout and wild-type mouse liver tissues.
• Analyze mitochondrial oxidative phosphorylation pathways identified through transcriptomic analysis of liver samples.
• Correlate CRIP1 expression levels with pro-inflammatory and anti-inflammatory gene profiles across diverse immune cell subsets from single-cell RNA sequencing data.
• Investigate CRIP1-dependent metabolic and immune response changes under chronic low-grade inflammation induced by periodontal pathogens.

Strengths

• Data integrates findings from multiple experimental models: CRIP1 knockout mice and human single-cell RNA sequencing.
• Analyses cover specific biological processes: zinc transport, iron metabolism, oxidative phosphorylation, and inflammatory regulation.
• Released under a permissive CC BY 4.0 license in 2026.

Limitations

• Dataset is extremely small (17.1 KB), containing a summary document rather than raw numerical or sequence data tables.
• No columnar data or sample records are provided, limiting direct computational analysis.
• Findings are confined to specific tissues (liver, peripheral mononuclear cells) and conditions studied.

Provenance

Source

DoYeon Kim via figshare.

Collection Method

Transcriptomic analysis of CRIP1 knockout and wild-type mouse liver tissues; single-cell RNA sequencing of human peripheral mononuclear cells from healthy and periodontitis patients.

Time Range

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Freshness

Last updated March 26, 2026.

Geography

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