Molecular Mechanisms of Insulin Resistance in PCOS: A Scoping Review

A scoping review systematically mapping molecular disturbances in insulin signaling and carbohydrate metabolism in Polycystic Ovary Syndrome (PCOS). The document, authored by Mikołaj Kisiała and last updated in April 2026, includes peer-reviewed studies from January 2018 to May 2025 retrieved from PubMed, Embase, and Web of Science. It focuses on mechanisms like IRS/PI3K/AKT signaling defects, GLUT4 regulation, and androgen-mediated metabolic dysfunction across tissues including ovary, liver, and muscle.

Use Cases

• Literature synthesis for molecular pathways in PCOS based on the review's systematic mapping of insulin signaling defects.
• Identifying research gaps in human tissue studies based on the noted predominance of rodent and cell line model evidence.
• Informing experimental design for validating key mechanisms like GLUT4 trafficking or inflammation based on the highlighted recurrent pathways.

Strengths

• Systematic review methodology covering studies from January 2018 to May 2025.
• Explicitly licensed under CC-BY-4.0 for open reuse.
• Focus on multiple tissue types including granulosa cells, liver, adipose, and muscle.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 49.6 KB file size indicates a limited scope, likely a summary document rather than a primary dataset.

Provenance

Source

figshare, author Mikołaj Kisiała.

Collection Method

Systematic scoping review of studies from PubMed, Embase, and Web of Science.

Time Range

Studies published between January 2018 and May 2025.

Freshness

Last updated 2026-04-13 04:35:52; freshness should be verified.

Geography

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