Mouse TAPBPR Functional Analysis: MHC-I Peptide Repertoire Data

Mouse TAPBPR protein shows functional similarity to its human counterpart in shaping the Major Histocompatibility Complex class I immunopeptidome. The 13.6 KB dataset, authored by Juliana Bernardi Aggio and last updated in April 2026, contains results from experiments comparing mouse TAPBPR's interactions with H2-Db and H2-Kb alleles. Findings include its role as a peptide exchange catalyst and its promotion of peptides with C-terminal methionine on H2-Kb.

Use Cases

• Compare peptide editing functions between mouse and human TAPBPR based on the described functional similarity.
• Analyze allele-specific binding affinity of TAPBPR based on the sustained interaction with H2-Db compared to H2-Kb.
• Investigate peptide selection bias based on the promotion of peptides with C-terminal methionine on H2-Kb.
• Model MHC-I peptide loading catalysis based on the described peptide exchange function in the presence of high-affinity peptides.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• File size is 13.6 KB, enabling quick download and inspection.
• Last update was 2026-04-15, indicating recent availability.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Juliana Bernardi Aggio via figshare.

Collection Method

Experimental characterization of mouse TAPBPR in cell lines, likely involving immunopeptidomics.

Time Range

Experimental timeframe not specified.

Freshness

Last updated 2026-04-15 04:21:56.

Geography

Geographic coverage not specified.