Multi-Omics Investigation of Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Muling Deng published Table 2_Multi-omics investigation of perineural invasion in head and neck squamous cell carcinoma: neuroimmune mechanisms and clinical implications.xlsx on figshare in May 2026. The dataset likely contains results from an integrative multi-omics analysis of perineural invasion in HNSCC, including transcriptomic, proteomic, single-cell, and spatial transcriptomic data. It includes a protein-based prognostic signature and findings on immune infiltration and TLR2-related signaling.

Use Cases

• Stratifying patient survival risk based on the protein-based signature (ADIPOQ, MB, PLIN1, ADH1B) described in the results.
• Investigating immune-suppressed phenotypes and predicted immunotherapy sensitivity in PNI-positive/high-risk tumors.
• Analyzing spatial patterns of PNI scores and neural programs using spatial transcriptomic data.
• Exploring candidate super-enhancer target genes (MYL4, CMYA5, TNNT3) linked to PNI-associated biology.

Strengths

• Integrates multiple data types: transcriptomic, proteomic, single-cell, and spatial transcriptomic data.
• Includes functional validation data from pharmacologic inhibition experiments using the TLR2 inhibitor C29 in FaDu cells.
• Dataset is openly licensed under CC-BY-4.0.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (10.6 KB), suggesting it contains summary results rather than raw multi-omics data.

Provenance

Source

figshare

Collection Method

Integrative multi-omics analysis using public datasets and an independent clinical cohort.

Freshness

Last updated 2026-05-12 05:43:51; freshness should be verified.