Neural Stem Cell-Derived Extracellular Vesicle Responses in Spinal Cord Injury Model

A 656.6 KB document by Kristyna Sintakova, last updated in June 2026, details experimental results on spinal cord injury organotypic slices. The study evaluates the neuroprotective and anti-apoptotic effects of small extracellular vesicles derived from SPC-01 and iMR-90 neural stem cell sources. Results indicate modulation of pathways including PTEN/STAT3 signaling and cytoskeletal stability.

Use Cases

• Analyze neuroprotective protein expression changes based on sEV treatment mentioned in the description
• Compare anti-apoptotic effects between different neural stem cell sources (SPC-01 vs. iMR-90) based on the experimental design
• Investigate cytoskeletal integrity and inhibitory signaling pathways (e.g., Nogo-A, RhoA) modulated after injury

Strengths

• Data is openly licensed under CC-BY-4.0, facilitating reuse.
• The description provides a detailed methodological and results summary for context.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a 656.6 KB DOCX file, indicating a small-scale, document-based data release.

Provenance

Source

figshare

Collection Method

Experimental study using an in vitro rat model of spinal cord injury.

Freshness

Last updated 2026-06-03 04:47:35; freshness should be verified