Neuro-Ophthalmic Complications of Tuberculosis Treatment: Systematic Review

22 studies (N=260,430) were included in this systematic review and meta-analysis. The work, authored by Ahmed A. Alessa and published on figshare in May 2026, evaluates the incidence and risk factors for neuro-ophthalmic complications related to tuberculosis and its treatment.

Use Cases

• Estimate incidence of ethambutol optic neuropathy (EON) based on pooled incidence rate of 1.54%
• Identify risk factors for EON based on reported odds ratios for renal impairment and hypertension
• Compare neuro-ophthalmic manifestations in tuberculous meningitis (TBM) based on reported rates of cranial nerve palsy, papilledema, and optic atrophy
• Evaluate biomarkers for subclinical neurotoxicity based on comparison of visual evoked potential (VEP) and optical coherence tomography (OCT)
• Assess factors for visual recovery in EON based on reported associations with younger age and earlier drug discontinuation

Strengths

• Analysis includes 260,430 participants from 22 studies, providing a substantial sample size.
• Follows PRISMA 2020 guidelines, suggesting a structured and transparent review methodology.
• Provides specific quantitative results, including pooled incidence rates, odds ratios, and risk ratios.

Limitations

• The dataset is a 16.7 KB DOCX document, likely containing only the review's text and tables, not the underlying raw study data.
• Row count and column-level documentation for any potential tabular data within the document are unknown.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of literature from PubMed, Scopus, Embase, Web of Science, Cochrane Library, and Google Scholar.

Time Range

Literature search up to September 30, 2025.

Freshness

Last updated 2026-05-29 04:44:46