NGF Administration Effects on GnRH Phenotype in Aging Mouse Hypothalamic Stem Cells

Experimental data from a study on nerve growth factor (NGF) administration in aging mice. The dataset likely contains measurements of hormone levels, immunofluorescence results, and transcriptomic profiles related to GnRH neuron differentiation. It was authored by Jiao Luo and uploaded to figshare on 2026-04-24.

Use Cases

• Analyze the relationship between NGF dosage and serum hormone levels (LH, FSH, testosterone) based on the described time-series measurements.
• Investigate cellular phenotype changes based on described GnRH immunoreactivity and Sox2/GnRH co-localization data from immunofluorescence.
• Study signaling pathway enrichment based on the transcriptomic profiling and qPCR data mentioned in the description.
• Model the in vitro differentiation of hypothalamic neural stem cells into GnRH-secreting neurons based on the described three-dimensional culture system results.

Strengths

• Data is associated with a detailed experimental methodology described in the input, including multiple time points and dosage levels.
• The dataset is shared under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• The dataset is very small (10.5 KB), indicating limited scope or a summary-level table rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical analysis.

Provenance

Source

figshare

Collection Method

Data generated from laboratory experiments on senescence-accelerated mouse P8 (SAMP8) models and in vitro stem cell cultures.

Freshness

Last updated 2026-04-24 05:40:51; freshness should be verified.