Yak Cardiac Molecular Atlas Under Nutritional Supplementation on the Qinghai-Tibet Plateau

The Qinghai-Tibet Plateau is the geographic scope for this dataset. It contains an integrative transcriptomic and proteomic atlas of cardiac tissue from 12 male Muli yaks subjected to different nutritional regimens over a 60-day intervention period. The data includes 140 differentially expressed genes and 254 differentially expressed proteins, with analysis of 4,080 gene-protein pairs, authored by Yiqun Chen and last updated in April 2026.

Use Cases

• Identify biomarkers for nutritional status in ruminants based on the coordinated induction of selenoproteins GPX1 and SELENOW.
• Study post-transcriptional regulatory mechanisms based on the decoupling between mRNA and protein expression levels.
• Analyze immune quiescence in cardiac tissue based on the attenuation of stress-responsive effectors like ULBP13 and GZMB.
• Train classification models for nutritional cohorts based on the perfect discriminatory capacity (AUC=1.00) of GPX1 and SELENOW.

Strengths

• Integrates two molecular strata with 4,080 cognate gene-protein pairs analyzed.
• Includes specific quantitative results, such as 140 differentially expressed genes and 254 differentially expressed proteins.
• Data is licensed under CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 6.6 MB, which may indicate limited scope or a focused subset of data.

Provenance

Source

figshare, authored by Yiqun Chen.

Collection Method

Data generated from RNA sequencing and data-independent acquisition mass spectrometry on myocardial specimens from a randomized 60-day intervention study.

Time Range

Intervention period was 60 days; specific years are not provided.

Freshness

Last updated 2026-04-14 12:38:56; freshness should be verified.

Geography

Qinghai-Tibet Plateau.