TgF344-AD Rat Model Data on Oropharyngeal Dysphagia and Amyloid Beta Pathology

Nine male TgF344-AD and six Wildtype Fisher 344 rats underwent deglutition assessments and PET imaging at 11 months of age. The dataset, authored by M. J. Cullins and last updated in April 2026, contains results linking amyloid beta pathology in specific brain regions to significant changes in swallowing and oral processing.

Use Cases

• Correlating amyloid beta levels in brainstem nuclei with swallowing onset delays based on PET imaging results.
• Analyzing changes in aerodigestive coordination, such as apnea duration, based on videofluoroscopic swallow study data.
• Investigating the relationship between amyloid pathology in the nucleus ambiguus and aberrant post-swallow breathing patterns.
• Comparing oral processing metrics like bolus size and mastication rate between transgenic and wild-type rat groups.

Strengths

• Data is derived from a controlled animal model study with 15 subjects (9 transgenic, 6 wild-type).
• Includes multimodal assessments: PET imaging for amyloid beta and videofluoroscopy for swallowing function.
• Released under a permissive CC-BY-4.0 license for open reuse.
• Focuses on a specific, understudied consequence of Alzheimer's disease at an early-middle stage timepoint.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 36.4 KB, indicating limited scope, likely containing summary results rather than raw data.

Provenance

Source

M. J. Cullins via figshare.

Collection Method

Experimental data from deglutition assessments and PET imaging in a rat model.

Time Range

Corresponds to an early-middle stage disease progression point (11 months of age in rats).

Freshness

Last updated 2026-04-13 05:30:29; freshness should be verified.

Geography

Laboratory study; geographic coverage is not specified.