Meta-Analysis of PD-1/PD-L1 Inhibitors Plus Chemotherapy for Advanced Endometrial Cancer

Ten randomized controlled trials encompassing 4,052 patients were included in this systematic review and meta-analysis. The study, authored by Zhilong Huang and published on figshare in 2026, evaluates the efficacy and safety of PD-1/PD-L1 inhibitors combined with chemotherapy as a first-line treatment for advanced or metastatic endometrial cancer. It reports pooled outcomes including progression-free survival, overall survival, and treatment-related adverse events.

Use Cases

• Compare progression-free and overall survival outcomes between combination therapy and chemotherapy alone based on the reported median survival times.
• Assess the relative risk of different response types (complete response, partial response) based on the reported relative risk values.
• Analyze the safety profile of combination therapy based on the reported common treatment-related adverse events.
• Validate meta-analysis findings for dMMR and pMMR patient subgroups based on the conclusion regarding differential survival benefits.

Strengths

• Analysis includes data from 10 randomized controlled trials, a standard for high-quality evidence.
• Pooled results are based on a substantial patient population of 4,052 individuals.
• Reports specific numerical outcomes, including median survival times and relative risks with confidence intervals.

Limitations

• The dataset is very small (29.5 KB), suggesting it contains only summary-level meta-analysis results, not patient-level data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analytical tasks.

Provenance

Source

Systematic review and meta-analysis of randomized controlled trials identified via PubMed, Embase, Web of Science, the Cochrane Library, and ClinicalTrials.gov.

Collection Method

Meta-analysis performed to pool outcomes from included studies.

Time Range

Literature search conducted from database inception to November 26, 2025.

Freshness

Last updated 2026-06-01 05:23:03; freshness should be verified.