Quinolone Antibiotics and Pemphigoid Adverse Events from FDA FAERS Database

Table 2 from a pharmacovigilance study by Xin Li, last updated April 2026, analyzes reports of pemphigoid linked to quinolone antibiotics. The dataset contains 183 identified reports from the FDA Adverse Event Reporting System (FAERS), with disproportionality analysis results for specific drugs like ofloxacin and ciprofloxacin. It includes findings on latency, demographic subgroups, and corroboration with published literature.

Use Cases

• Assessing disproportionality signals for specific quinolone antibiotics based on reporting odds ratios (RORs) mentioned in the description
• Analyzing latency patterns for drug-induced pemphigoid based on the reported onset within 30 days of drug initiation
• Investigating demographic susceptibility patterns based on subgroup analyses by age and sex referenced in the results
• Corroborating real-world evidence with literature findings based on the described interaction analysis

Strengths

• Contains 183 specific reports of quinolone-associated pemphigoid identified from the FAERS database
• Provides disproportionality signals with specific ROR values for drugs like ofloxacin (ROR=2.75) and ciprofloxacin (ROR=2.31)
• Includes subgroup analyses by age, sex, and reporter type as described in the methods
• Integrates findings with published literature evidence for consistency assessment

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data may reflect reporting bias inherent to spontaneous adverse event reporting systems like FAERS

Provenance

Source

FDA Adverse Event Reporting System (FAERS) database and published literature.

Collection Method

Analysis of FAERS reports using disproportionality methods (ROR, PRR, BCPNN) and interaction analysis with literature.

Time Range

Temporal coverage of the underlying FAERS data is not specified.

Freshness

Last updated 2026-04-15 05:22:41; freshness should be verified

Geography

Spatial coverage is not specified, but FAERS is a U.S. system with international reports.