Meta-Analysis of Perioperative Esketamine for Postoperative Sleep Disturbance Prevention

A systematic review and meta-analysis of 22 randomized controlled trials assessing the efficacy and safety of perioperative esketamine for preventing postoperative sleep disturbance in adults. The document, authored by Jinfang Zeng and last updated in June 2026, pools risk ratios for sleep disturbance incidence across postoperative days 1-7 and analyzes adverse events. The certainty of evidence for early outcomes is rated as moderate.

Use Cases

• Assessing the efficacy of esketamine for reducing early postoperative sleep disturbance based on pooled risk ratios.
• Evaluating the safety profile of perioperative esketamine based on analyzed adverse event data.
• Informing the design of future clinical trials based on identified limitations in sleep assessment methods and evidence gaps.

Strengths

• Includes 22 randomized controlled trials, providing a quantitative synthesis of evidence.
• Risk ratios with 95% confidence intervals are provided for specific postoperative days (POD1, POD2, POD3, POD7).
• Analyses include risk of bias assessment, GRADE certainty rating, trial sequential analysis, and sensitivity analyses.

Limitations

• The dataset is a 134.5 KB document; the underlying tabular meta-analysis data is not directly accessible.
• Evidence mainly reflects subjective binary sleep outcomes; effects on objective sleep parameters are uncertain.
• Clinical heterogeneity exists due to differences in surgical populations, patient characteristics, and esketamine regimens.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of trials from PubMed, Embase, Cochrane Library, and CNKI up to March 2026.

Time Range

Trials from database inception to 10 March 2026.

Freshness

Last updated 2026-06-03 06:08:21.