Immune Cell and Protein Signatures in Acute Gouty Arthritis

Peng Zhang's dataset contains results from a multi-omics study of acute gouty arthritis. The data includes findings from Mendelian randomization, CyTOF immune profiling of 56 patient and control samples, single-cell RNA-seq re-analysis, and plasma proteomics from 104 individuals. It was last updated on 2026-05-26.

Use Cases

• Validate genetic associations between immune cell phenotypes and gout risk based on Mendelian randomization results.
• Analyze peripheral CD4+ naïve T cell remodeling during acute flares using CyTOF and single-cell transcriptomic data.
• Investigate plasma protein levels of MMP1 and S100A12 as potential biomarkers for acute gout and recurrence risk.
• Study predicted cell-cell communication pathways, such as MIF–CXCR2 and ANXA1–FPR1 signaling, between T cells and myeloid cells.

Strengths

• Multi-modal data integration from CyTOF, single-cell RNA-seq, plasma proteomics, and Mendelian randomization.
• Includes data from a clinical cohort with 25 acute gout patients, 22 recurrent patients, and 9 healthy controls.
• Proteomic validation was performed in independent training (n=40) and validation (n=64) cohorts.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• The dataset is very small at 10.7 KB, indicating it likely contains summary results rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred from the description.

Provenance

Source

Peng Zhang via figshare.

Collection Method

Integrated analysis using bidirectional Mendelian randomization, CyTOF, single-cell RNA-seq re-analysis, and Olink plasma proteomics.

Freshness

Last updated 2026-05-26 06:03:53; freshness should be verified.

Geography

Study cohorts include individuals of European ancestry (GWAS) and Chinese cohorts (experimental analyses).