Sedation Strategies for Gastrointestinal Endoscopy: A Network Meta-Analysis of 60 RCTs

A systematic review and network meta-analysis of 60 randomised controlled trials involving 7,071 patients, evaluating 32 pharmacological sedation regimens for therapeutic gastrointestinal endoscopy. The dataset was created by Hui Jiang and last updated on 2026-04-21. Outcomes analyzed include procedural interference, hypoxia, hypotension, bradycardia, recovery time, and patient satisfaction.

Use Cases

• Compare the efficacy of ketamine-propofol versus propofol-opioid regimens based on reported outcomes like hypoxia and hypotension.
• Rank sedation strategies using cluster analysis results mentioned for efficacy and safety domains.
• Assess the certainty of evidence for different outcomes using the GRADE framework ratings described.
• Identify potential effect modifiers through meta-regression results as indicated in the description.

Strengths

• Includes data from 60 randomised controlled trials, a substantial evidence base.
• Analyzes 32 distinct pharmacological regimens, allowing for broad comparisons.
• Reports specific statistical results, such as relative risks and confidence intervals for key outcomes.
• Uses established methodological frameworks like Cochrane RoB 2.0 and GRADE for quality assessment.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (51.5 KB), indicating limited raw data scope.

Provenance

Source

figshare

Collection Method

Systematic review and network meta-analysis of trials from PubMed, Embase, and CENTRAL.

Freshness

Last updated 2026-04-21 04:23:04; freshness should be verified.