Placental Transcriptome Profiles for Congenital Chagas Disease Transmission

Transcriptomic analysis of placental tissues from deliveries of congenitally infected, exposed but uninfected, and unexposed/uninfected newborns. The dataset is 139.1 KB and was authored by Sofia Apodaca, last updated on 2026-03-18. It includes findings on differential gene expression, gene set enrichment, and co-expression network analysis related to Trypanosoma cruzi transmission.

Use Cases

• Identify placental gene expression signatures associated with congenital transmission based on differential expression analysis.
• Investigate the role of extracellular matrix and cell adhesion pathways in fetal infection using gene set enrichment results.
• Analyze cell type-specific transcriptional changes in trophoblasts and immune-associated placental cells.
• Validate hub genes like ENPP1 and SLC16A10 identified through co-expression network analysis.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• Analysis includes comparisons across three distinct clinical groups (M+B+, M+B−, M−B−).
• Findings are based on RNA-seq data and include multiple analytical layers (differential expression, gene set enrichment, co-expression networks).

Limitations

• Row and column counts are unknown, limiting suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 139.1 KB, indicating a limited scope of raw or processed data.

Provenance

Source

figshare, author Sofia Apodaca.

Collection Method

RNA-seq transcriptomic analysis of placental tissues.

Freshness

Last updated 2026-03-18 06:43:05.