Multi-ancestry data from a study using Mendelian randomization to identify plasma protein drug targets for gastric cancer. The dataset, 154.8 MB in size and authored by Peng Zhi, was last updated on May 1, 2026. It includes results for European and East Asian populations, identifying 13 ancestry-specific protein targets.
Use Cases
- Identify ancestry-specific drug targets based on Mendelian randomization results for European and East Asian populations
- Validate potential tumor-suppressive or oncogenic functions of proteins like NME4 and ICAM5
- Explore cross-ancestry therapeutic potential of repurposable drugs such as digoxin
- Investigate cellular expression patterns of targets in epithelial and Pit mucous cells
Strengths
- Identifies 13 ancestry-specific protein targets, including 4 for European and 9 for East Asian populations
- Includes experimental validation results for NME4 and ICAM5 in cell lines and tissue samples
- Released under a permissive CC-BY-4.0 license for open reuse
Limitations
- Column-level documentation is absent; field semantics must be inferred after download
- Row count is unknown, which may limit suitability assessment
Provenance
- Source
- figshare
- Collection Method
- Mendelian randomization and colocalization analysis of plasma proteome data
- Freshness
- Last updated 2026-05-01 04:19:29
- Geography
- European and East Asian populations