Platycodin D Effects on Cardiac Hypertrophy and Apoptosis in a Mouse Model

A dataset from a 2026 study investigating the therapeutic effects of Platycodin D (PLD) on isoprenaline-induced heart failure in mice. The data, shared by Yingrui Li on figshare under a CC-BY-4.0 license, likely contains results from a 4-week treatment period with PLD doses of 12.5, 25, and 50 mg/kg/d. It supports findings on the inhibition of the p53-dependent BCL-2/Bax/caspase-3 signaling pathway.

Use Cases

• Analyzing dose-response relationships of Platycodin D based on the described 12.5, 25, and 50 mg/kg/d treatment groups.
• Modeling the p53-mediated apoptotic pathway based on the described BCL-2/Bax/caspase-3 signaling components.
• Comparing therapeutic effects between PLD and the p53 inhibitor pifithrin-α (PFT-α) as referenced in the study methods.

Strengths

• Dataset is openly shared under a permissive CC-BY-4.0 license.
• The underlying study includes specific experimental details such as treatment doses (12.5, 25, 50 mg/kg/d) and duration (4 weeks).
• File is provided in the widely accessible XLSX format.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 12.3 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Data generated from a controlled laboratory study using a mouse model of isoprenaline-induced heart failure.

Freshness

Last updated 2026-05-26 06:03:52; freshness should be verified.