PM2.5 and HDM Effects on Allergic Rhinitis via STING Pathway

Research data from a study investigating how PM2.5 exposure exacerbates house dust mite-induced allergic rhinitis. The dataset contains experimental results from bioinformatics analysis, mouse models, and human nasal epithelial cell cultures. It supports findings on nasal barrier disruption and the STING/NF-κB signaling pathway activation.

Use Cases

• Analyze the correlation between PM2.5 exposure levels and Th2 inflammation markers like IL-4, IL-5, IL-13, and IgE from the experimental results.
• Model the impact of STING inhibitor H-151 treatment on nasal epithelial barrier integrity metrics such as E-cadherin and Claudin-1 expression.
• Investigate the synergistic effects of combined PM2.5 and HDM exposure on rhinitis symptom scores and TNF/NF-κB signaling pathway activation data.

Strengths

• Data integrates findings from multiple experimental methods: bioinformatics, in vivo mouse models, and in vitro human cell cultures.
• The dataset is associated with a specific, peer-reviewed mechanistic hypothesis on the STING/NF-κB pathway.
• It is shared under a permissive CC BY 4.0 license, allowing for reuse and redistribution.

Limitations

• The dataset is small in scale at 1.7 MB, indicating limited raw data volume for large-scale statistical modeling.
• Specific structural details like row count, column names, and data formats are not provided in the metadata.
• The data originates from a single controlled study, limiting generalizability to broader populations or environmental conditions.

Provenance

Source

figshare, authored by Youwei Bao.

Collection Method

Generated from a combined research methodology including bioinformatics analysis of a human nasal transcriptome dataset, in vivo experiments with BALB/c mouse models, and in vitro experiments with Human Nasal Epithelial Cells (HNEpCs).

Freshness

Last updated on 2026-03-24.